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Update on romosozumab: a humanized monoclonal antibody to sclerostin

25 Mar 2014

Abstract excerpt

INTRODUCTION: Disorders with inactivating mutations of the SOST gene result in reduced or absent expression of sclerostin and are associated with high bone mass. Sclerostin is an important regulator of bone formation due to its inhibitory actions in the osteoanabolic Wnt signaling pathway. Advances in understanding the mechanisms of action of this signaling molecule have led to the development of a...

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PMID: 24665957
DOI: 10.1517/14712598.2014.895808

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