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Article

APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk.

PloS one - 1 Jan 2011

Geng Hua, Law Peggy P Y, Ng Maggie C Y, Li Ting, Liang Li-Yun, Ge Tian-Fang, Wong Kam-Bo, Liang Chun, Ma Ronald C, So Wing-Yee, Chan Juliana C N, Ho Yuan-Yuan

Abstract excerpt

BACKGROUND: The apolipoprotein E gene (APOE) coding polymorphism modifies the risks of Alzheimer's disease, type 2 diabetes, and coronary heart disease. Aside from the coding variants, single nucleotide polymorphism (SNP) of the APOE promoter has also been shown to modify the risk of Alzheimer's disease. METHODOLOGY/PRINCIPAL FINDINGS: In this study we investigate the genotype-function relationship of APOE...

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Source

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Identifiers

PMID: 22028770
DOI: 10.1371/journal.pone.0024669
PMCID: PMC3196492

Genes

APOE
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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