Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional mutation at position -155 in porcine APOE promoter affects gene expression.

BMC genetics - 9 May 2011

Li Shixin, Zhang Hao, Gao Ping, Chen Zanmou, Wang Chong, Li Jiaqi

Abstract excerpt

BACKGROUND: Apolipoprotein E, a component of the plasma lipoproteins, plays an important role in the transport and metabolism of cholesterol and other lipids. Three single nucleotide polymorphisms (SNPs) -491A>T, -219T>G and +113G>C in the regulatory region of human apolipoprotein E gene (APOE) change the promoter activity and are associated with a wide variety of disorders including Alzheimer disease (AD)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to APOE gene
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Share to Sequence Homology, Nucleic Acid

Share to Sus scrofa

Source

Open in PubMed Open full text

Identifiers

PMID: 21549015
DOI: 10.1186/1471-2156-12-40
PMCID: PMC3098798

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional mutation at position -155 in porcine APOE promoter affects gene expression.PMID 21549015Read ↗

APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk.Semantic proximity Read ↗

Functional Mutations in the microRNA-155 Promoter Modulate its Transcription Efficiency and Expression.Semantic proximity Read ↗

Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.Semantic proximity Read ↗

Genetic variants in ABCA1 promoter affect transcription activity and plasma HDL level in pigs.Semantic proximity Read ↗

Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene.Semantic proximity Read ↗

Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease.Semantic proximity Read ↗

Single-nucleotide polymorphisms and activity analysis of the promoter and enhancer of the pig lactase gene.Semantic proximity Read ↗

Identification of a functional apolipoprotein E promoter polymorphism regulating plasma apolipoprotein E concentration.Semantic proximity Read ↗

Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.Semantic proximity Read ↗

A functional variant in the porcine APOA2 promoter alters hepatic gene expression via RORα.Semantic proximity Read ↗

Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter.Semantic proximity Read ↗

Polymorphisms in the promoter region of the adiponectin (ADIPOQ) gene are presumably associated with transcription level and carcass traits in pigs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.