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Enzyme-assisted upconversion fluorescence-encoded biosensing system for simultaneous detection of multiple sites EGFR mutation.

Analytical and bioanalytical chemistry - 1 Jan 2025

Gao Haiyang, Si Gao, Wang Zhendong, Liu Yanju, Yang Huaixia, Miao Mingsan, Ma Lele

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutations play a key role in the development of a variety of cancers. Rapid detection and screening of EGFR mutation types in patients are of great significance for early treatment of patients. In this study, a highly sensitive fluorescent biosensing system based on lanthanide ion-doped multi-type upconversion nanoparticles (UCNPs) combined with polymerization reaction...

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PMID: 39579240
DOI: 10.1007/s00216-024-05660-8

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