Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGF-2- and TGF-β1-induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway.

Investigative ophthalmology & visual science - 21 Nov 2011

Chen Jian, Wong-Chong Julie, SundarRaj Nirmala

Abstract excerpt

PURPOSE: Downregulation of lumican and keratocan expression is an undesirable phenotypic change that occurs during corneal wound healing. The present study was intended to determine whether the activation of Jun N-terminal kinase (JNK)-signaling pathway is involved in their downregulation in TGF-β1- and FGF-2-activated keratocytes. METHODS: Keratocytes, isolated from rabbit corneal stroma, and cultured in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthracenes
Share to Chondroitin Sulfate Proteoglycans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Corneal Stroma

Share to Fibroblast Growth Factor 2

Share to Mitogen-Activated Protein Kinase 8

Share to Proteoglycans

Share to Transforming Growth Factor beta1

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 22025571
DOI: 10.1167/iovs.11-8078
PMCID: PMC3231797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGF-2- and TGF-β1-induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway.PMID 22025571Read ↗

Role of lumican in the corneal epithelium during wound healing.Semantic proximity Read ↗

Response of Lens Epithelial Cells to Injury: Role of Lumican in Epithelial-Mesenchymal TransitionSemantic proximity Read ↗

Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis.Semantic proximity Read ↗

Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling.Semantic proximity Read ↗

Keratocan Expression Is Increased in the Stroma of Keratoconus CorneasSemantic proximity Read ↗

Histological and microRNA Signatures of Corneal Epithelium in KeratoconusSemantic proximity Read ↗

Microarray analysis identified differentially expressed genes in keratocytes from keratoconus patientsSemantic proximity Read ↗

Proteomic and gene expression patterns of keratoconusSemantic proximity Read ↗

Roles of lumican and keratocan on corneal transparency.Semantic proximity Read ↗

C-Jun terminal kinases play an important role in regulating embryonic survival and eye development in vertebrates.Semantic proximity Read ↗

Preservation and expansion of the primate keratocyte phenotype by downregulating TGF-beta signaling in a low-calcium, serum-free medium.Semantic proximity Read ↗

Role of Fibroblast Growth Factor Receptor 2 (FGFR2) in Corneal Stromal ThinningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.