Article
Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling.
Advanced healthcare materials - 1 Sept 2020
Zhang Wei, Chen Jialin, Qu Mingli, Backman Ludvig J, Zhang Aini, Liu Haoyang, Zhang Xiaoping, Zhou Qingjun, Danielson Patrik
Abstract excerpt
Corneal injury due to ocular trauma or infection is one of the most challenging vision impairing pathologies that exists. Many studies focus on the pro-inflammatory and pro-angiogenic effects of interleukin-1β (IL-1β) on corneal wound healing. However, the effect of IL-1β on keratocyte phenotype and corneal repair, as well as the underlying mechanisms, is not clear. This study reports, for the first time, that...
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