Specificity of the suppression of metastatic phenotype by tyrosine and phenylalanine restriction.

doi:10.1007/BF00058152

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Article

Specificity of the suppression of metastatic phenotype by tyrosine and phenylalanine restriction.

Clinical & experimental metastasis - 1 Jan 2000

Elstad C A, Meadows G G, Abdallah R M

Abstract excerpt

Amino acid restriction modulates tumor growth, although effects on metastasis are poorly documented. We demonstrate that low levels of tyrosine (Tyr) and phenylalanine (Phe) suppress metastasis of B16-BL6 melanoma and that these effects are specific to these two amino acids. Weight loss and susta...

Topics

Animals
Body Weight
Female
Lung Neoplasms
Male
Melanoma, Experimental
Mice
Mice, Inbred C57BL
Neoplasm Metastasis
Phenotype
Phenylalanine
Tyrosine

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