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Article

Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaques.

PloS one - 1 Jan 2011

Siddiqui Roman A, Krawczak Michael, Platzer Matthias, Sauermann Ulrike

Abstract excerpt

In HIV infection, TLR7-triggered IFN-α production exerts a direct antiviral effect through the inhibition of viral replication, but may also be involved in immune pathogenesis leading to AIDS. TLR7 could also be an important mediator of vaccine efficacy. In this study, we analyzed polymorphisms in the X-linked TLR7 gene in the rhesus macaque model of AIDS. Upon resequencing of the TLR7 gene in 36 rhesus macaques...

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Source

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Identifiers

PMID: 22022401
DOI: 10.1371/journal.pone.0025474
PMCID: PMC3192768

Genes

TLR7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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