Article
The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection.
Immunogenetics - 1 Dec 2011
Reed Jason S, Sidney John, Piaskowski Shari M, Glidden Chrystal E, León Enrique J, Burwitz Benjamin J, Kolar Holly L, Eernisse Christopher M, Furlott Jessica R, Maness Nicholas J, Walsh Andrew D, Rudersdorf Richard A, Bardet Wilfried, McMurtrey Curtis P, O'Connor David H, Hildebrand William H, Sette Alessandro, Watkins David I, Wilson Nancy A
Abstract excerpt
Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characterized with regard to peptide binding, and a sixth was shown to be uninvolved. In this study, we...
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