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Article

A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis.

Oncotarget - 6 Dec 2016

Bong Yong-Sik, Assefnia Shahin, Tuohy Therese, Neklason Deborah W, Burt Randall W, Ahn Jaeil, Bueno De Mesquita Paul J, Byers Stephen W

Abstract excerpt

Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/β-catenin/TCF tumor suppressor pathway. The vitamin D receptor (VDR) is also implicated in cardiovascular and skin diseases as well as in immunity. Activated VDR can indirectly alter β-catenin nuclear localization and directly suppress β-catenin/TCF mediated transcriptional activity. We...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cell Transformation, Neoplastic

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Share to Receptors, Calcitriol

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Source

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Identifiers

PMID: 27768599
DOI: 10.18632/oncotarget.12768
PMCID: PMC5348337

Genes

VDR
APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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