Article
A novel predicted bromodomain-related protein affects coordination between meiosis and spermiogenesis in Drosophila and is required for male meiotic cytokinesis.
DNA and cell biology - 1 Sept 2010
Bergner Laura M, Hickman F Edward, Wood Kathleen H, Wakeman Carolyn M, Stone Hunter H, Campbell Tessa J, Lightcap Samantha B, Favors Sheena M, Aldridge Amanda C, Hales Karen G
Abstract excerpt
Temporal coordination of meiosis with spermatid morphogenesis is crucial for successful generation of mature sperm cells. We identified a recessive male sterile Drosophila melanogaster mutant, mitoshell, in which events of spermatid morphogenesis are initiated too early, before meiotic onset. Premature mitochondrial aggregation and fusion lead to an aberrant mitochondrial shell around premeiotic nuclei. Despite...
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