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Article

PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.

Autophagy - 1 Aug 2020

Lee Shinrye, Jeon Yu-Mi, Cha Sun Joo, Kim Seyeon, Kwon Younghwi, Jo Myungjin, Jang You-Na, Lee Seongsoo, Kim Jaekwang, Kim Sang Ryong, Lee Kea Joo, Lee Sung Bae, Kim Kiyoung, Kim Hyung-Jun

Abstract excerpt

TARDBP/TDP-43 (TAR DNA binding protein) proteinopathies are a common feature in a variety of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer disease (AD). However, the molecular mechanisms underlying TARDBP-induced neurotoxicity are largely unknown. In this study, we demonstrated that TARDBP proteinopathies induce impairment in...

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Identifiers

PMID: 31690171
DOI: 10.1080/15548627.2019.1686729
PMCID: PMC7469499

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