Article
Gastrointestinal stromal tumours.
The British journal of surgery - 1 Oct 2003
Connolly E M, Gaffney E, Reynolds J V
Abstract excerpt
BACKGROUND: Gastrointestinal stromal tumours (GISTs), previously classified as benign or malignant smooth muscle tumours, are the most common mesenchymal tumours of the gastrointestinal tract. GISTs express a growth factor receptor with tyrosine kinase activity, termed KIT. Mutations of KIT are common in malignant GISTs and lead to constitutional activation of tyrosine kinase function, which causes cellular...
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