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MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interaction.

Neurobiology of aging - 1 May 2012

Mansoori Nasim, Tripathi Manjari, Luthra Kalpana, Alam Rizwan, Lakshmy Ramakrishnan, Sharma Subhadra, Arulselvi Subramanyam, Parveen Shama, Mukhopadhyay Asok K

Abstract excerpt

Genetic risk factors play an important role in the pathogenesis of Alzheimer disease (AD) and vascular dementia (VaD). In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) genes and their correlation with plasma levels of homocysteine (Hcy) in AD and VaD cases and evaluated the gene-gene interaction (epistasis) with...

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PMID: 22015309
DOI: 10.1016/j.neurobiolaging.2011.09.018

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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