Article
The role of mutations in core protein of hepatitis B virus in liver fibrosis.
Virology journal - 26 Nov 2009
Mohamadkhani Ashraf, Jazii Ferdous Rastgar, Poustchi Hossein, Nouraein Omidreza, Abbasi Shahsanam, Sotoudeh Masoud, Montazeri Ghodratollah
Abstract excerpt
The core protein of hepatitis B virus encompasses B- and T-cell immunodominant epitopes and subdivided into two domains: the N-terminal and the functional C-terminal consisted phosphorylation sites. Mutations of the core gene may change the conformation of the core protein or cause alteration of important epitopes in the host immune response. In this study twenty nine men (mean age 40 +/- 9 years old) with...
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