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Article

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Johnson L M, Kayne P S, Kahn E S, Grunstein M

Abstract excerpt

Repression of transcription from the silent mating loci (HML alpha and HMRa) is essential for mating ability in Saccharomyces cerevisiae. This silencing is known to require at least five proteins (SIR1, SIR2, SIR3, SIR4, and histone H4) and is accompanied by a change in chromatin structure. We show here that four positions of histone H4 (N-terminal residues 16, 17, 18, and 19) are crucial to silencing. HML alpha...

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Identifiers

PMID: 2201024
DOI: 10.1073/pnas.87.16.6286
PMCID: PMC54518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.PMID 2201024Read ↗

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.Semantic proximity Read ↗

Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Specific repression of the yeast silent mating locus HMR by an adjacent telomere.Semantic proximity Read ↗

Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Redundant roles for histone H3 N-terminal lysine residues in subtelomeric gene repression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Insights into the impact of histone acetylation and methylation on Sir protein recruitment, spreading, and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.Semantic proximity Read ↗

Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in the nucleosome core enhance transcriptional silencing.Semantic proximity Read ↗

Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing.Semantic proximity Read ↗

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