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A Critical Look at Entropy-Based Gene-Gene Interaction Measures.

Genetic epidemiology - 1 Jul 2016

Lee Woojoo, Sjölander Arvid, Pawitan Yudi

Abstract excerpt

Several entropy-based measures for detecting gene-gene interaction have been proposed recently. It has been argued that the entropy-based measures are preferred because entropy can better capture the nonlinear relationships between genotypes and traits, so they can be useful to detect gene-gene interactions for complex diseases. These suggested measures look reasonable at intuitive level, but so far there has...

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PMID: 27229752
DOI: 10.1002/gepi.21974

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