Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia.

European journal of anaesthesiology - 1 Nov 2007

Iohom G, Ni Chonghaile M, O'Brien J K, Cunningham A J, Fitzgerald D F, Shields D C

Abstract excerpt

BACKGROUND AND OBJECTIVE: The objectives of this study were, firstly, to characterize the inter-patient variability in the dose of propofol required to achieve a bispectral index <70 and 'time to eye opening' following propofol infusion and, secondly, to determine if the pharmacodynamic parameter 'time to achieve bispectral index <70' was influenced by genotype of the sex-linked drug receptor gene GABRE or if...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pharmacogenetics
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, X

Share to Cytochrome P-450 CYP2B6

Share to Electroencephalography

Share to Oxidoreductases, N-Demethylating

Share to Propofol

Share to Receptors, GABA-A

Source

Identifiers

PMID: 17555608
DOI: 10.1017/S0265021507000476

Genes

GABRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia.PMID 17555608Read ↗

Pharmacogenetics, plasma concentrations, clinical signs and EEG during propofol treatment.Semantic proximity Read ↗

The impact of genetic factors on response to anaesthetics.Semantic proximity Read ↗

Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic ManagementSemantic proximity Read ↗

Pharmacogenomics of commonly used intravenous anesthetics.Semantic proximity Read ↗

Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and PharmacodynamicsSemantic proximity Read ↗

Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics.Semantic proximity Read ↗

Pharmacogenetics and anesthetic drugs.Semantic proximity Read ↗

CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects.Semantic proximity Read ↗

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia.Semantic proximity Read ↗

Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia.Semantic proximity Read ↗

Effect of CYB2B6 (c.516G>T), CYP2C9 (c.1075A>C) and UGT1A9 (c.98T>C) polymorphisms on propofol pharmacokinetics in patients submitted to colonoscopy: a cohort study.Semantic proximity Read ↗

Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.