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Article

Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.

Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2012

Ma Junhe, Edlich Frank, Bermejo Guillermo A, Norris Kristi L, Youle Richard J, Tjandra Nico

Abstract excerpt

The human protein Bax sits at a critical regulatory junction of apoptosis, or programmed cell death. Bax exists in equilibrium between cytosolic and mitochondria-associated forms that shifts toward the latter when Bax is activated by proapoptotic proteins. Activated Bax changes conformation, inserts into the mitochondrial outer membrane (MOM), oligomerizes, and induces MOM permeabilization, causing the release of...

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Identifiers

PMID: 23213219
DOI: 10.1073/pnas.1217094110
PMCID: PMC3529058

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