Article
Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene.
Chemico-biological interactions - 20 Mar 2007
Wickliffe Jeffrey K, Herring Stacy M, Hallberg Lance M, Galbert Lori A, Masters Oscar E, Ammenheuser Marinel M, Xie Jingwu, Friedberg Errol C, Lloyd R Stephen, Abdel-Rahman Sherif Z, Ward Jonathan B
Abstract excerpt
1,3-Butadiene (BD) is a well-documented mutagen and carcinogen in rodents and is currently classified as a probable carcinogen in humans. Studies investigating workers exposed to BD indicate that, in some plants, there may be an increased genetic risk, and that polymorphisms in biotransformation...
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