Article
1,3-butadiene: cancer, mutations, and adducts. Part V: Hemoglobin adducts as biomarkers of 1,3-butadiene exposure and metabolism.
Research report (Health Effects Institute) - 1 Mar 2000
Swenberg J A, Christova-Gueorguieva N I, Upton P B, Ranasinghe A, Scheller N, Wu K Y, Yen T Y, Hayes R
Abstract excerpt
1,3-Butadiene (BD) is an important chemical used largely in the manufacture of synthetic rubber and thermoplastic resins. In addition, it has been identified in cigarette smoke, automobile exhaust, and gasoline vapor. The objective of this research was to develop highly sensitive and specific assays for the detection and quantitation of hemoglobin adducts of three BD metabolites: 1,2-epoxy-3-butene (BDO),...
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