Article
Measurement of plasma or urinary metabolites and Hprt mutant frequencies following inhalation exposure of mice and rats to 3-butene-1,2-diol.
Chemico-biological interactions - 20 Mar 2007
Walker Dale M, McDonald Jacob D, Meng Quanxin, Kracko Dean A, Bauer Michael J, Seilkop Steven K, Walker Elizabeth L, Henderson Rogene F, Walker Vernon E
Abstract excerpt
Studies were performed to determine if the detoxification pathway of 1,3-butadiene (BD) through 3-butene-1,2-diol (BD-diol) is a major contributor to mutagenicity in BD-exposed mice and rats. First, female and male mice and rats (4-5 weeks old) were exposed by nose-only for 6h to 0, 62.5, 200, 625, or 1250 ppm BD or to 0, 6, 18, 24, or 36 ppm BD-diol primarily to establish BD and BD-diol exposure concentrations...
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