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Article

PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity.

Nature neuroscience - 16 Oct 2011

Sumioka Akio, Brown Travis E, Kato Akihiko S, Bredt David S, Kauer Julie A, Tomita Susumu

Abstract excerpt

The reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPA receptor (AMPAR) auxiliary subunit TARPγ-8 could be a result of a reduction in AMPAR expression or of the direct action of γ-8. We generated TARPγ-8Δ4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic transmission and AMPARs were reduced in the mutant mice, but extrasynaptic AMPAR expression...

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Identifiers

PMID: 22002768
DOI: 10.1038/nn.2952
PMCID: PMC3206644

Genes

TARP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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