Does elevated hemoglobin F modulate the phenotype in Hb SD-Los Angeles?

Abstract excerpt

Hemoglobin (Hb) SD-Los Angeles compound heterozygotes usually have a severe clinical course although the effect of an elevated Hb F on the clinical phenotype has not been reported previously. We describe 5 Kuwaiti children with Hb SD associated with Hb F levels >20%. They all presented with sickling-related symptoms by < or =2 years of age and have been followed for 3-15 years. All had severe clinical courses...

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