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Article

Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region.

The Journal of biological chemistry - 23 Feb 2001

Eyries M, Michaud A, Deinum J, Agrapart M, Chomilier J, Kramers C, Soubrier F

Abstract excerpt

Angiotensin-converting enzyme (ACE), an enzyme that plays a major role in vasoactive peptide metabolism, is a type 1 ectoprotein, which is released from the plasma membrane by a proteolytic cleavage occurring in the stalk sequence adjacent to the membrane anchor. In this study, we have discovered...

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Source

Identifiers

PMID: 11076943
DOI: 10.1074/jbc.M007706200

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11076943-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region.PMID 11076943Read ↗

Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease.Semantic proximity Read ↗

An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.Semantic proximity Read ↗

Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE.Semantic proximity Read ↗

Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain.Semantic proximity Read ↗

A Novel Splice-Site Mutation in Angiotensin I-Converting Enzyme (ACE) Gene, c.3691+1G>A (IVS25+1G>A), Causes a Dramatic Increase in Circulating ACE through Deletion of the Transmembrane AnchorSemantic proximity Read ↗

The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity.Semantic proximity Read ↗

Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints.Semantic proximity Read ↗

Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding.Semantic proximity Read ↗

A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.Semantic proximity Read ↗

Proteolytic release of membrane proteins: studies on a membrane-protein-solubilizing activity in CHO cells.Semantic proximity Read ↗

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Phenotyping Angiotensin-Converting Enzyme in Blood: A Necessary Approach for Precision Medicine.Semantic proximity Read ↗

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