Article
Breast cancer genome-wide association studies: there is strength in numbers.
Oncogene - 26 Apr 2012
Fanale D, Amodeo V, Corsini L R, Rizzo S, Bazan V, Russo A
Abstract excerpt
Breast cancer (BC) is a heterogeneous disease that exhibits familial aggregation. Family linkage studies have identified high-penetrance genes, BRCA1, BRCA2, PTEN and TP53, that are responsible for inherited BC syndromes. Moreover, a combination of family-based and population-based approaches indicated that genes involved in DNA repair, such as CHEK2, ATM, BRIP and PALB2, are associated with moderate risk....
Topics
- Apoptosis Regulatory Proteins
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- High Mobility Group Proteins
- Humans
- MAP Kinase Kinase Kinase 1
- Microfilament Proteins
- Multifactorial Inheritance