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Genetic Insights Into Allergic Contact Dermatitis: Reassessing the Role of LCE3C_LCE3B Deletion.

Contact dermatitis - 1 Mar 2026

Ben Lamine Zeineb, Moussa Amen, Bouhoula Marwa, Gerisha Razene, Sabbagh Sarra, Kacem Imen, Aloui Asma, Chatti Souheil, Brahem Aicha, Zemni Ramzi, Ben Hadj Slama Foued

Abstract excerpt

BACKGROUND: Allergic contact dermatitis (ACD) is a multifactorial inflammatory skin disorder. Polysensitisation, defined as hypersensitivity to ≥ 3 unrelated allergens, reflects a more severe clinical form. The LCE3C_LCE3B deletion, implicated in skin barrier dysfunction, has a yet unclear role in the susceptibility to ACD and polysensitisation. OBJECTIVE: This study aims to evaluate the association between...

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Identifiers

PMID: 41391883
DOI: 10.1111/cod.70058
PMCID: PMC12872337

Genes

ACD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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