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Article

A kinesin mutation that uncouples motor domains and desensitizes the gamma-phosphate sensor.

The Journal of biological chemistry - 21 Jul 2000

Brendza K M, Sontag C A, Saxton W M, Gilbert S P

Abstract excerpt

Conventional kinesin is a processive, microtubule-based motor protein that drives movements of membranous organelles in neurons. Amino acid Thr(291) of Drosophila kinesin heavy chain is identical in all superfamily members and is located in alpha-helix 5 on the microtubule-binding surface of the catalytic motor domain. Substitution of methionine at Thr(291) results in complete loss of function in vivo. In vitro,...

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Identifiers

PMID: 10767290
DOI: 10.1074/jbc.M001124200
PMCID: PMC1560104

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Source receipt: pubmed, retrieved 7 Sept 2026.

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