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Article

Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

1 Jan 2011

Abstract excerpt

Glioblastomas (GBM) are a paradigm for the investigation of cancer stem cells (CSC) in solid malignancies. The susceptibility of GBM CSC to standard chemotherapeutic drugs is controversial as the existing literature presents conflicting experimental data. Here, we summarize the experimental evidence on the resistance of GBM CSC to alkylating chemotherapeutic agents, with a special focus on temozolomide (TMZ). The...

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PMID: 21988793
DOI: 10.1186/1476-4598-10-128

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