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Article

Cancer stem cells as mediators of treatment resistance in brain tumors: status and controversies.

Neoplasia (New York, N.Y.) - 1 Nov 2007

Sakariassen Per Ø, Immervoll Heike, Chekenya Martha

Abstract excerpt

Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumor-related mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and radiotherapy is only transiently effective, illustrating the profound impact of treatment resistance on prognosis. Recent studies suggest that a small subpopulation of cancer stem cells (CSCs) has...

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Identifiers

PMID: 18030356
DOI: 10.1593/neo.07658
PMCID: PMC2077879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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