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Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.

Cells - 11 Mar 2021

Biserova Karina, Jakovlevs Arvids, Uljanovs Romans, Strumfa Ilze

Abstract excerpt

Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies. CSCs have attracted remarkable research interest due to their role in tumor resistance to chemotherapy and radiation treatment as well as recurrence. Extensive research has been devoted to the role of CSCs...

Topics

Animals
Antineoplastic Agents
Biomarkers, Tumor
Brain Neoplasms
Cell Lineage
Drug Resistance, Neoplasm
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Glioblastoma
Humans
Neoplastic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Radiation Tolerance

Tumor Microenvironment

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Open in PubMed Open full text

Identifiers

PMID: 33799798
DOI: 10.3390/cells10030621
PMCID: PMC8000844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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