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Article

VP24 is a molecular determinant of Ebola virus virulence in guinea pigs.

The Journal of infectious diseases - 1 Nov 2011

Mateo Mathieu, Carbonnelle Caroline, Reynard Olivier, Kolesnikova Larisa, Nemirov Kirill, Page Audrey, Volchkova Valentina A, Volchkov Viktor E

Abstract excerpt

In sharp contrast to human and nonhuman primates, guinea pigs and some other mammals resist Ebola virus (EBOV) replication and do not develop illness upon virus inoculation. However, serial passaging of EBOV in guinea pigs results in a selection of variants with high pathogenicity. In this report, using a reverse genetics approach, we demonstrate that this dramatic increase in EBOV pathogenicity is associated...

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Share to Ebolavirus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemorrhagic Fever, Ebola

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Identifiers

PMID: 21987737
DOI: 10.1093/infdis/jir338

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