Article
Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.
Cancer causes & control : CCC - 1 Dec 2011
Chokkalingam Anand P, Bartley Karen, Wiemels Joseph L, Metayer Catherine, Barcellos Lisa F, Hansen Helen M, Aldrich Melinda C, Guha Neela, Urayama Kevin Y, Scélo Ghislaine, Chang Jeffrey S, Month Stacy R, Wiencke John K, Buffler Patricia A
Abstract excerpt
BACKGROUND: Acute leukemias of childhood are a heterogeneous group of malignancies characterized by cytogenetic abnormalities, such as translocations and changes in ploidy. These abnormalities may be influenced by altered DNA repair and cell cycle control processes. METHODS: We examined the association between childhood acute lymphoblastic leukemia (ALL) and 32 genes in DNA repair and cell cycle pathways using a...
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