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Article

Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia.

Cancer genomics & proteomics - 1 Jan 2000

Chen Chao-Chun, Chang Wen-Shin, Pei Jen-Sheng, Kuo Chien-Chung, Wang Chung-Hsing, Wang Yun-Chi, Hsu Pei-Chen, He Jie-Long, Gu Jian, Bau DA-Tian, Tsai Chia-Wen

Abstract excerpt

BACKGROUND/AIM: The capacity for non-homologous end-joining (NHEJ) repair plays a pivotal role in maintaining genome stability and in carcinogenesis. However, there is little literature on the involvement of NHEJ-related genes in childhood acute lymphocytic leukemia (ALL). Our study aimed to elucidate the impact of polymorphisms of X-ray repair cross-complementing group 4 (XRCC4) (rs6869366, rs2075685, rs2075686,...

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Identifiers

PMID: 38423600
DOI: 10.21873/cgp.20436
PMCID: PMC10905275

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