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DIAGNOSTIC X RAYS, DNA REPAIR GENES AND CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

1 Jul 2003

Abstract excerpt

A model for childhood leukemia proposes that characteristic chromosomal translocations can arise in utero and that for most cases a second hit occurring postnatally will be necessary. Possible causal mechanisms for leukemias are environmental factors such as ionizing radiation from x rays and inherited susceptibility from polymorphisms in DNA repair genes. We performed a case-control study of childhood acute...

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PMID: 12852472
DOI: 10.1097/00004032-200307000-00012

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