Article
Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients.
Immunological investigations - 1 Jan 2011
Rosentul Diana C, Plantinga Theo S, Papadopoulos Antonios, Joosten Leo A B, Antoniadou Anastasia, Venselaar Hanka, Kullberg Bart-Jan, van der Meer Jos W M, Giamarellos-Bourboulis Evangelos J, Netea Mihai G
Abstract excerpt
Opportunistic infections are the main cause of morbidity and death among HIV-positive patients. Most of these infections are linked to the immunodeficiency due to low CD4+ counts. However, not all patients with low CD4+ counts are equally susceptible to infections, and we hypothesize that variability in genes of innate immunity may also play an important role. The dectin-1/CARD9 pathway is crucial for recognition...
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