Article
Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.
Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2010
Plantinga Theo S, Hamza Omar J M, Willment Janet A, Ferwerda Bart, van de Geer Nicole M D, Verweij Paul E, Matee Mecky I N, Banahan Kathy, O'neill Luke A J, Kullberg Bart-Jan, Brown Gordon D, van der Ven André J A M, Netea Mihai G
Abstract excerpt
BACKGROUND: The occurrence of oropharyngeal candidiasis (OPC) in combination with HIV disease progression is a very common phenomenon. However, not all HIV-infected patients develop OPC, even when they progress to low CD4 T-cell counts. Because T-cell immunity is defective in AIDS, the innate defence mechanisms are likely to have a central role in antifungal immunity in these patients. We investigated whether...
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