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Article

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

Cancer cell - 17 Jan 2012

Ling Jianhua, Kang Ya'an, Zhao Ruiying, Xia Qianghua, Lee Dung-Fang, Chang Zhe, Li Jin, Peng Bailu, Fleming Jason B, Wang Huamin, Liu Jinsong, Lemischka Ihor R, Hung Mien-Chie, Chiao Paul J

Abstract excerpt

Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic ductal adenocarcinoma (PDAC). However, how NF-κB is activated in PDAC is not yet understood. Here, we report that pancreas-targeted IKK2/β inactivation inhibited NF-κB activation and PDAC development in Kras(G12D) and Kras(G12D);Ink4a/Arf(F/F) mice, demonstrating a mechanistic link between IKK2/β and Kras(G12D) in PDAC...

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Identifiers

PMID: 22264792
DOI: 10.1016/j.ccr.2011.12.006
PMCID: PMC3360958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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