Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of the aconitase gene in Corynebacterium glutamicum causes strong selection pressure for secondary mutations inactivating citrate synthase.

Journal of bacteriology - 1 Dec 2011

Baumgart Meike, Mustafi Nurije, Krug Andreas, Bott Michael

Abstract excerpt

The aconitase gene acn of Corynebacterium glutamicum is regulated by four transcriptional regulators, indicating that the synthesis of this enzyme is carefully controlled. To understand the causes for this elaborate regulation, the properties of the Δacn-1 deletion mutant were analyzed in detail. The mutant was glutamate auxotrophic in glucose minimal medium, showed a strong growth defect, and secreted large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aconitate Hydratase
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Citrate (si)-Synthase

Share to Corynebacterium glutamicum

Share to Gene Deletion

Share to Gene Expression Regulation, Bacterial

Share to Gene Silencing

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 21984793
DOI: 10.1128/JB.05465-11
PMCID: PMC3232852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of the aconitase gene in Corynebacterium glutamicum causes strong selection pressure for secondary mutations inactivating citrate synthase.PMID 21984793Read ↗

Construction and properties of aconitase mutants of Escherichia coli.Semantic proximity Read ↗

Alterations in the transcription factors GntR1 and RamA enhance the growth and central metabolism of Corynebacterium glutamicum.Semantic proximity Read ↗

L-Glutamine as a nitrogen source for Corynebacterium glutamicum: derepression of the AmtR regulon and implications for nitrogen sensing.Semantic proximity Read ↗

Improving lysine production by Corynebacterium glutamicum through DNA microarray-based identification of novel target genes.Semantic proximity Read ↗

Glutamate synthase of Corynebacterium glutamicum is not essential for glutamate synthesis and is regulated by the nitrogen status.Semantic proximity Read ↗

Two genetically-distinct and differentially-regulated aconitases (AcnA and AcnB) in Escherichia coli.Semantic proximity Read ↗

Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum.Semantic proximity Read ↗

A leuC mutation leading to increased L-lysine production and rel-independent global expression changes in Corynebacterium glutamicum.Semantic proximity Read ↗

Mutations in the ilvN gene mitigate growth inhibitory effect of cysteine in Corynebacterium glutamicum.Semantic proximity Read ↗

Disruption of genes for the enhanced biosynthesis of α-ketoglutarate in Corynebacterium glutamicum.Semantic proximity Read ↗

Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutamicum.Semantic proximity Read ↗

The three tricarboxylate synthase activities of Corynebacterium glutamicum and increase of L-lysine synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.