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Article

Disruption of genes for the enhanced biosynthesis of α-ketoglutarate in Corynebacterium glutamicum.

Canadian journal of microbiology - 1 Mar 2012

Jo Jae-Hyung, Seol Hye-Young, Lee Yun-Bom, Kim Min-Hong, Hyun Hyung-Hwan, Lee Hyune-Hwan

Abstract excerpt

The development of microbial strains for the enhanced production of α-ketoglutarate (α-KG) was investigated using a strain of Corynebacterium glutamicum that overproduces of l-glutamate, by disrupting three genes involved in the α-KG biosynthetic pathway. The pathways competing with the biosynthesis of α-KG were blocked by knocking out aceA (encoding isocitrate lyase, ICL), gdh (encoding glutamate...

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PMID: 22356563
DOI: 10.1139/w11-132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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