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Article

Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.

PloS one - 1 Jan 2011

Sun Hung-Yu, Ou Nai-Ying, Wang Shainn-Wei, Liu Wen-Chun, Cheng Ting-Fang, Shr Shiou-Jiuan, Sun Koun-Tem, Chang Ting-Tsung, Young Kung-Chia

Abstract excerpt

Molecular covariation of highly polymorphic viruses is thought to have crucial effects on viral replication and fitness. This study employs association rule data mining of hepatitis C virus (HCV) sequences to search for specific evolutionary covariation and then tests functional relevance on HCV replication. Data mining is performed between nucleotides in the untranslated regions 5' and 3'UTR, and the amino acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21980483
DOI: 10.1371/journal.pone.0025530
PMCID: PMC3182228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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