Article
A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals.
PloS one - 1 Jan 2011
Roffman Joshua L, Nitenson Adam Z, Agam Yigal, Isom Marlisa, Friedman Jesse S, Dyckman Kara A, Brohawn David G, Smoller Jordan W, Goff Donald C, Manoach Dara S
Abstract excerpt
BACKGROUND: Responding to errors is a critical first step in learning from mistakes, a process that is abnormal in schizophrenia. To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated...
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