Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia.

doi:10.1093/schbul/sbn064

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Article

Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia.

Schizophrenia bulletin - 1 Jan 2010

Haraldsson Haraldur Magnus, Ettinger Ulrich, Magnusdottir Brynja B, Sigmundsson Thordur, Sigurdsson Engilbert, Ingason Andres, Petursson Hannes

Abstract excerpt

The catechol-O-methyltransferase (COMT) enzyme catabolizes dopamine. The val(158)met single nucleotide polymorphism (rs4680) in the COMT gene has received considerable attention as a candidate gene for schizophrenia as well as for frontally mediated cognitive functions. Antisaccade performance is a good measure of frontal lobe integrity. Deficits on the task are considered a trait marker for schizophrenia. The...

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PMID: 18562342
DOI: 10.1093/schbul/sbn064
PMCID: PMC2800134

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