Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells

Abstract excerpt

BACKGROUND: Invasion is an important early step in the metastatic cascade and is the primary cause of death of prostate cancer patients. In order to invade, cells must detach from the primary tumor. Cell-cell and cell-ECM interactions are important regulators of cohesion--a property previously demonstrated to mediate cell detachment and invasion. The studies reported here propose a novel role for α5β1...

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