Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications.

doi:10.1016/j.ebiom.2024.105096

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications.

EBioMedicine - 1 May 2024

Christiansen Colette, Potier Louis, Martin Tiphaine C, Villicaña Sergio, Castillo-Fernandez Juan E, Mangino Massimo, Menni Cristina, Tsai Pei-Chien, Campbell Purdey J, Mullin Shelby, Ordoñana Juan R, Monteagudo Olga, Sachdev Perminder S, Mather Karen A, Trollor Julian N, Pietilainen Kirsi H, Ollikainen Miina, Dalgård Christine, Kyvik Kirsten, Christensen Kaare, van Dongen Jenny, Willemsen Gonneke, Boomsma Dorret I, Magnusson Patrik K E, Pedersen Nancy L, Wilson Scott G, Grundberg Elin, Spector Tim D, Bell Jordana T

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) susceptibility is influenced by genetic and environmental factors. Previous findings suggest DNA methylation as a potential mechanism in T2D pathogenesis and progression. METHODS: We profiled DNA methylation in 248 blood samples from participants of European ancestry from 7 twin cohorts using a methylation sequencing platform targeting regulatory genomic regions encompassing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Complications

Share to Diabetes Mellitus, Type 2

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Profiling

Share to Genome-Wide Association Study

Share to Otx Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 38574408
DOI: 10.1016/j.ebiom.2024.105096
PMCID: PMC11004697

Genes

OTX2
RGL3
NGB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications.PMID 38574408Read ↗

Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic TraitsSemantic proximity Read ↗

Increased DNA methylation variability in type 1 diabetes across three immune effector cell typesSemantic proximity Read ↗

DNA Methylation Changes Associated With Type 2 Diabetes and Diabetic Kidney Disease in an East Asian Population.Semantic proximity Read ↗

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.Semantic proximity Read ↗

Epigenetic Profiling of Type 2 Diabetes Mellitus: An Epigenome-Wide Association Study of DNA Methylation in the Korean Genome and Epidemiology StudySemantic proximity Read ↗

DNA Methylation and Type 2 Diabetes: Novel Biomarkers for Risk Assessment?Semantic proximity Read ↗

Network analysis after epigenome wide methylation study revealed JUP as a regulator of co-methylated risk-module for T2DMSemantic proximity Read ↗

Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study.Semantic proximity Read ↗

The Potential Use of DNA Methylation Biomarkers to Identify Risk and Progression of Type 2 DiabetesSemantic proximity Read ↗

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Semantic proximity Read ↗

Novel epigenetic determinants of type 2 diabetes in Mexican-American families.Semantic proximity Read ↗

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.