Article
Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated-M1 Macrophage Polarization-Dependent Vascular Smooth Muscle Cell Phenotypic Conversion.
Oxidative medicine and cellular longevity - 1 Jan 2022
Xing Yujie, Pan Shuo, Zhu Ling, Cui Qianwei, Tang Zhiguo, Liu Zhongwei, Liu Fuqiang
Abstract excerpt
OBJECTIVE: The objective of this study was to investigate the involved mechanisms of advanced glycation end product- (AGE-) exacerbated atherosclerosis (AS). METHODS: Toll-like receptor 4 (TLR4) inhibitor was administrated to type 2 diabetes mellitus (T2DM) AS rats. Atherosclerotic plaque, M1 macrophage infiltration, and VSMCs phenotypes were evaluated. AGE-exposed primary macrophages were treated with specific...
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