Article
Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease.
Kidney international - 1 Aug 2007
Wang Y, Wang Y P, Zheng G, Lee V W S, Ouyang L, Chang D H H, Mahajan D, Coombs J, Wang Y M, Alexander S I, Harris D C H
Abstract excerpt
Macrophage infiltration of the kidney is a prominent feature associated with the severity of renal injury and progressive renal failure. To determine the influence of macrophages in renal disease models in the absence of endogenous T and B cells, we performed adoptive transfer of macrophages into severe combined immunodeficient (SCID) mice. In this study, macrophages were isolated from the spleens of BALB/c mice...
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