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Base excision repair and homologous recombination are required for prevention of a chronic DNA damage response in Saccharomyces cerevisiae.

DNA repair - 1 Jan 2026

Nepal Yogesh, Ahmed Sanjida, Berry Armand M, Mahmood Anika, Holland Cory L, Lewis L Kevin

Abstract excerpt

The chromosomes within eukaryotic cells experience many types of damage that are generated naturally via endogenous processes. The specific pathways that are most critical for repair of such endogenously produced DNA lesions have not been identified. Previous work revealed that budding yeast mutants deficient in double-strand break repair exhibit a persistent DNA damage checkpoint response leading to chronically...

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PMID: 41411878
DOI: 10.1016/j.dnarep.2025.103915

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