Article
CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity.
Experimental dermatology - 1 Apr 2005
Nieuwenhuis Edward E S, Gillessen Silke, Scheper Rik J, Exley Mark A, Taniguchi Masaru, Balk Steven P, Strominger Jack L, Dranoff Glenn, Blumberg Richard S, Wilson S Brian
Abstract excerpt
CD1d-restricted T-cells are activated by glycolipids presented by the major histocompatibility complex class-Ib molecule CD1d, found on the surface of antigen-presenting cells (APC). This interaction between APC, most notably dendritic cells (DC), and CD1d-restricted T-cells is an important regulatory step in the initiation of adaptive immune responses. It is well known that DC play a crucial role in the...
Topics
- Administration, Topical
- Animals
- Antigen Presentation
- Antigens, CD1
- Antigens, CD1d
- Cell Line
- Dendritic Cells
- Dermatitis
- Dermatitis, Contact
- Dose-Response Relationship, Drug
- Glycolipids
- Hypersensitivity
- Killer Cells, Natural