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Article

Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.

The Journal of experimental medicine - 14 Feb 2011

Saito Masako, Nagasawa Masayuki, Takada Hidetoshi, Hara Toshiro, Tsuchiya Shigeru, Agematsu Kazunaga, Yamada Masafumi, Kawamura Nobuaki, Ariga Tadashi, Tsuge Ikuya, Nonoyama Shigeaki, Karasuyama Hajime, Minegishi Yoshiyuki

Abstract excerpt

Hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by recurrent staphylococcal infections and atopic dermatitis associated with elevated serum IgE levels. Although defective differentiation of IL-17-producing CD4(+) T cells (Th17) partly accounts for the susceptibility to staphylococcal skin abscesses and pneumonia, the pathogenesis of atopic manifestations in HIES still remains an enigma. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21300911
DOI: 10.1084/jem.20100799
PMCID: PMC3039860

Genes

STAT3
FOXP3
TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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